HEAT DIFFUSION BASED GENETIC NETWORK ANALYSIS

摘要

Methods and devices are provided for performing heat diffusion based genetic analysis. A network comprising a plurality of genes is defined an initial heat score is assigned to each of the plurality of genes. A threshold value for evaluating whether heat will be diffused from each of the plurality of genes within the network is assigned. Heat from at least one of the plurality of genes is diffused across the network, and after reaching equilibrium, the network is partitioned into a hierarchy of subnetworks according to an amount and a direction of heat exchange amongst each of the plurality of genes, and a statistical significance of the partitioned network and/or hierarchy of partitioned networks is assessed.