SELECTIVE INHIBITORS FOR PROTEIN KINASES AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

摘要

The present invention provides a compound of formula (I) or the salt thereof:;wherein R is at least one selected from the group consisting of unsubstituted C1-4 alkyl, C1-4 alkyl substituted by C6-18 aryl or —OR1, and —C(═O)Z. The compound is a type-S protein kinase inhibitor, which binds to an ATP-binding site and a substrate-recognition site of a protein kinase simultaneously. The present invention further provides a pharmaceutical composition, which includes a compound of formula (I) or a salt and a pharmaceutically acceptable carrier thereof. The present invention further provides a use of a compound of formula (I) or a salt thereof, which is for the manufacture of a protein kinase inhibitor as a drug.

主权项

1. A compound of formula (I) or the salt thereof: wherein R is at least one selected from the group consisting of unsubstituted C1-4 alkyl, C1-4 alkyl substituted by C6-18 aryl or —OR1, and —C(═O)Z; R1 is at least one selected from the group consisting of hydrogen, C1-4 alkyl and wherein Z is —C(NH2)CR2; and R2 is at least one selected from the group consisting of unsubstituted phenyl, phenyl substituted by hydroxyl or C1-4 alkoxyl, unsubstituted C5-10 cycloheteroaryl, C5-10 cycloheteroaryl substituted by C1-4 alkoxycarbonyl, carboxyl, and an ester group.