Chiral Synthesis of Pyrrolidine Core Compounds en route to Neuronal Nitric Oxide Synthase Inhibitors

摘要

A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.

主权项

1. A method of preparing a chiral pyrrolidine core compound, said method comprising:
providing a racemic di-N-Boc-protected 3,4-trans-(aminopyridinyl)alkyl-substituted pyrrolidine alcohol; protecting said amino group with a Boc reagent, to provide a tri-Boc-protected pyrrolidine compound; and resolving said racemate by camphanic acid esterification, to provide separable diastereomers.