SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)-PHTHALIMIDES AND -1-OXOISOINDOLINES AND METHOD OF REDUCING TNFALPHA LEVELS

摘要

Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNFα in a mammal.

主权项

1. A 2,6-dioxopiperidine selected from the group consisting of (a) a compound of the formula: in which: one of X and Y is C═O and the other of X and Y is C═O or CH2; (i) each of R1, R2, R3, and R4, independently of the other, is halo, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms or (if) one of R1, R2, R3, and R4 is —NHR5 and the remaining of R1, R2, R3, and R4 are hydrogen; R5 is hydrogen or alkyl of 1 to 8 carbon atoms; R6 is hydrogen, alkyl of 1 to 8 carbon atoms, benzyl, or halo; provided that R6 is other than hydrogen if X and Y are C═O and (i) each of R1, R2, R3, and R4 is fluoro or (if) one of R1, R2, R3, or R4 is amino; and (h) the acid addition salts of said compounds which contain a nitrogen atom capable of being protonated.