发明名称 METHOD FOR PREPARING BIOLOGICAL TISSUES FOR USE IN BIOLOGICAL PROSTHESES
摘要 A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid.
申请公布号 US2016095957(A1) 申请公布日期 2016.04.07
申请号 US201514966675 申请日期 2015.12.11
申请人 Sorin Group Italia S.r.l. 发明人 Strasly Marina;Rolando Giovanni
分类号 A61L27/36 主分类号 A61L27/36
代理机构 代理人
主权项 1. A method of treating a biological tissue for use in a biological prosthesis, the method comprising the steps: eliminating phospholipids from the biological tissue by treating the biological tissue with an elimination solution at a temperature of 15° C. to 65° C., the elimination solution including 1,2-octanediol at a concentration of 1% v/v to 25% v/v and ethanol at a concentration of 25% to 49% v/v in a buffer at a pH of 4 to 9; fixing the biological tissue treated with the elimination solution by treating the biological tissue, the fixing solution including glutaraldehyde at a concentration of 0.10% v/v to 2.00% v/v in a buffer at a pH of 5 to 8; and detoxifying the biological tissue treated with the fixing solution by treating the biological tissue with a detoxifying solution at a temperature above 20° C., the detoxifying solution including taurine or homocysteic acid in a buffer at a pH of 4 to 9.
地址 Milano IT