Inactivating pathogens with hydrogen peroxide for vaccine production

摘要

C /NRPnrh/DCC/GRSW708352_1 DOC-10/29/2012 INACTIVATING PATHOGENS WITH HYDROGEN PEROXIDE FOR VACCINE The present disclosure provides methods for producing a vaccine composition containing a pathogen that is rendered noninfectious by exposure to hydrogen peroxide. The methods disclosed herein are suitable for the preparation of vaccines for a wide variety of pathogens, including viruses, bacteria and parasites. The disclosure also provides vaccine compositions (medicaments) containing a pathogen inactivated by exposure to hydrogen peroxide. Methods for eliciting an immune response in a subject by administering vaccine compositions containing a hydrogen peroxide inactivated pathogen are also provided.