LABELLED CARBOXYLIC ACIDS AND THEIR USES IN MOLECULAR IMAGING

摘要

The present invention pertains generally to the field of imaging compounds, and more specifically to certain 2,2-dialkyl radionuclide-labelled carboxylic acids suitable for PEWT, SPECT and/or DNP imaging. Also described are uses of such compounds in the imaging of, inter alia, cancer tumors, metastasis, Alzheimer's disease and multiple sclerosis.

主权项

1. A composition comprising a tracer, wherein the tracer is a labelled 2,2-di-C1-4-alkylpropanoic acid, 2,2-di-C1-4-alkylbutanoic acid, 2,2-di-C1-4-alkylpentanoic acid, or the corresponding carboxylate, wherein the tracer is labelled with:
a radionuclide and/or a label suitable for polarisation using dynamic nuclear polarisation (DNP).