Allergen Peptide Fragments and Use Thereof for Treatment of Birch Pollen Allergies

摘要

The present invention relates generally to in vivo methods and compositions designed for allergen specific immunotherapy. The compositions include contiguous overlapping peptide fragments which together form an entire amino acid sequence of an allergen.

主权项

1. A composition comprising a plurality of contiguous overlapping peptide fragments 30 to 73 amino acids in length which peptide fragments consist of peptides within SEQ ID NOs: 8 and 9 which together comprise the entire amino acid sequence of a birch pollen profilin allergen (SEQ ID NO: 10), wherein said fragments are capable of inducing a T cell response in patients hypersensitive to said allergen
wherein the reactivity of said peptides to IgE antibodies of subjects who are allergic to birch pollen profilin allergen is significantly reduced or eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen profilin allergen is retained.