| 发明名称 |
COMPOSITIONS AND METHODS FOR TRANSIENT UP-REGULATION OF MYC IN B-CELL LYMPHOMAS FOR ENHANCING P53 INDEPENDENT APOPTOTIC RESPONSES TO CHEMOTHERAPY |
| 摘要 |
Compositions and methods useful for the treatment of cancer, particularly lymphoma, are disclosed. |
| 申请公布号 |
US2016095873(A1) |
申请公布日期 |
2016.04.07 |
| 申请号 |
US201514875094 |
申请日期 |
2015.10.05 |
| 申请人 |
THE CHILDREN'S HOSPITAL OF PHILADELPHIA |
发明人 |
Thomas-Tikhonenko Andrei;Sotillo-Pineiro Elena |
| 分类号 |
A61K31/704;A61K31/506 |
主分类号 |
A61K31/704 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the treatment of cancer in a patient in need thereof, comprising administration of an effective amount of an glycogen synthase kinase 3β (GSK3β) inhibitor in combination with an apoptosis inducing chemotherapeutic agent, said inhibitor being effective to stabilize myc, thereby enhancing apoptosis inducing action of said chemotherapeutic agent. |
| 地址 |
Philadelphia PA US |
