发明名称 |
MULTIPLEX TP53/CEN17/B CELL GENE-PROTEIN CO-DETECTION ASSAY AND UNIQUELY SPECIFIC PROBES FOR 19q12, INSR, ATM, DLEU2, TP53, and 13q12 |
摘要 |
Disclosed herein are multiplex methods for co-detecting a B cell marker, TP53 nucleic acid, and Chromosome 17 centromere DNA in a single sample. Samples stained for the B cell marker (e.g., CD79a protein), TP53 nucleic acid, and Chromosome 17 centromere DNA may allow for the identification of the subtype of chronic lymphocytic leukemia (CLL) with the 17p deletion. The methods feature staining the B cell marker (e.g., CD79a) a first distinct color, TP53 in a second distinct color, and chromosome 17 centromere DNA in a third distinct color. Further disclosed are nucleic acid probes specific for 19q12, INSR, ATM, DLEU2, TP53, and 13q12. |
申请公布号 |
WO2016050681(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
WO2015EP72231 |
申请日期 |
2015.09.28 |
申请人 |
VENTANA MEDICAL SYSTEMS, INC.;F. HOFFMANN-LA ROCHE AG |
发明人 |
ALEXANDER, NELSON;GROGAN, THOMAS M.;HENRICKSEN, LEIGH A.;KELLY, BRIAN D.;NITTA, HIRO;STANISLAW, STACEY;TUBBS, ALISA |
分类号 |
G01N33/574;C12Q1/68 |
主分类号 |
G01N33/574 |
代理机构 |
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