发明名称 |
HIGHLY POTENT ACID ALPHA-GLUCOSIDASE WITH ENHANCED CARBOHYDRATES |
摘要 |
Recombinant human alpha glucosidase (rhGAA) composition derived from CHO cells that contains a more optimized glycan composition consisting of a higher amount of rhGAA containing N-glycans carrying mannose-6-phosphate (M6P) or bis-M6P than conventional rhGAAs, along with low amount of non-phosphorylated high mannose glycans, and low amount of terminal galactose on complex oligosaccharides. Compositions containing the rhGAA, and methods of use are described. |
申请公布号 |
WO2016054231(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
WO2015US53252 |
申请日期 |
2015.09.30 |
申请人 |
AMICUS THERAPEUTICS, INC. |
发明人 |
GOTSCHALL, RUSSELL;DO, HUNG |
分类号 |
C12N5/07;C12N5/10 |
主分类号 |
C12N5/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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