| 发明名称 |
ANTI-B7-H5 ANTIBODIES AND THEIR USES |
| 摘要 |
The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H5 ligand of the B7-H5:CD28H pathway, and to the uses of such molecules in the treatment and diagnosis of autoimmune disease, transplant rejection and other inflammatory diseases. |
| 申请公布号 |
US2016096891(A1) |
申请公布日期 |
2016.04.07 |
| 申请号 |
US201414893463 |
申请日期 |
2014.05.27 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY ;AMPLIMMUNE, INC. |
发明人 |
CHEN LIEPING;YAO SHENG;LIU LINDA;LANGERMANN SOLOMON |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody or antigen binding fragment thereof comprising six complementarity determining regions (CDRs),
wherein the CDRs comprise (1) the three light chain CDRs of SEQ ID NO:11 and the three heavy chain CDRs of SEQ ID NO:9, or (2) the three light chain CDRs of SEQ ID NO:15 and the three heavy chain CDRs of SEQ ID NO:13, and wherein the antibody or antigen binding fragment thereof binds to B7-H5. |
| 地址 |
BALTIMORE MD US |
