发明名称 |
Cysteine engineered fibronectin type III domain binding molecules |
摘要 |
Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN 3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizig a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules: and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically. |
申请公布号 |
AU2014334627(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
AU20140334627 |
申请日期 |
2014.10.13 |
申请人 |
JANSSEN BIOTECH, INC. |
发明人 |
GOLDBERG, SHALOM;JACOBS, STEVEN;LIN, TRICIA;O'NEIL, KARYN |
分类号 |
C07K14/435;A61K38/22;C07K16/28;C12N1/20 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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