ANTIBODIES TO MASP-2

摘要

The invention relates to antibodies to MASP-2 and functional equivalents thereof. In particular, the invention relates to MASP-2 antibodies capable of inhibiting the function of MASP-2. The invention furthermore discloses MASP-2 epitopes, wherein antibodies recognising said epitopes are in particularly useful for inhibiting MASP-2 activity. The invention also relates to methods of producing said antibodies, methods of inhibiting MASP-2 activity as well as to pharmaceutical compositions comprising the MASP-2 antibodies.

主权项

1. An antibody or antigen-binding fragment thereof specifically recognising and binding a polypeptide fragment of human MASP-2 consisting of the CCP1, CCP2 and serine protease domains (aa 293 to 686 of SEQ ID NO:1), wherein said antibody or antigen-binding fragment thereof is capable of displacing one or more reference antibodies in a competitive ELISA assay, wherein the one or more reference antibodies selected from the group consisting of:
(i) the monoclonal antibody produced by the hybridoma cell line deposited under the deposition number 03050904; (ii) the monoclonal antibody produced by the hybridoma cell line deposited under the deposition number DSM ACC2657 (iii) the monoclonal antibody produced by the hybridoma cell e deposited under the deposition number DSM ACC2660; (iv) the monoclonal antibody produced by the hybridoma cell line deposited under the deposition number DSM ACC2658; and (v) the monoclonal antibody produced by the hybridoma cell line deposited under the deposition number DSM ACC2659, wherein the antibody, or antigen-binding fragment thereof, is capable of inhibiting C4 deposition.