GLIOBLASTOMA MULTIFORME-REACTIVE ANTIBODIES AND METHODS OF USE THEREOF

摘要

The present disclosure is generally related to antibodies that bind specifically to glioblastoma multiforme (GBM) cells. In particular, the present disclosure provides compositions comprising human single chain or full-length antibodies that bind tumor cells. Additionally the present disclosure provides methods of using the anti-GBM antibodies.

主权项

1. An isolated antibody that binds specifically to glioblastoma multiforme (GBM) tumor sphere cells, wherein the anti-GBM antibody comprises an antigen binding site that comprises:
a heavy chain comprising (i) complementarity determining region (CDR)-H1 comprising SEQ ID NO: 67, (ii) CDR-H2 comprising SEQ ID NO: 69, and (iii) CDR-H3 comprising SEQ ID NO 71, and a light chain comprising (iv) CDR-L1 comprising SEQ ID NO: 75, (v) CDR-L2 comprising SEQ ID NO 77, and (vi) CDR-L3 comprising SEQ ID NO 79.