发明名称 |
COMPOSITIONS AND METHODS FOR TREATMENT WITH HEMOPEXIN |
摘要 |
Compositions and methods are provided for therapeutic treatment using recombinant Hemopexin molecules having sufficient sialyation and/or absence of neutral glycans to allow for sufficient circulation to remove free heme from a biological organism. In other embodiments, a recombinant Hemopexin molecule is provided for therapeutic treatment having a percentage of neutral glycans to total glycans in a range of from about 2 to about 30 percent as measured by HPLC after labelling with fluorescent probe 2-aminobenzoic acid. Methods of treatment and making a recombinant Hemopexin molecule are also described. |
申请公布号 |
WO2016054072(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
WO2015US52990 |
申请日期 |
2015.09.29 |
申请人 |
BAYER HEALTHCARE LLC |
发明人 |
MCLEAN, KIRK;HERMISTON, TERRY;BROOKS, ALAN;FELDMAN, RICHARD |
分类号 |
A01N63/00;C12N5/07;C12N5/071;C12N15/00 |
主分类号 |
A01N63/00 |
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