METHODS OF TREATING SYSTEMIC LUPUS ERYTHEMATOSUS USING A DOMAIN ANTIBODY DIRECTED AGAINST CD28
摘要
Methods of treating autoimmune diseases, such as systemic lupus erythematosus using domain antibodies that specifically bind human CD28 are provided. The methods may comprise at least one administration cycle comprising one dose of the domain antibody. The method reduces symptoms of systemic lupus erythematosus compared to placebo.
申请公布号
WO2016054218(A1)
申请公布日期
2016.04.07
申请号
WO2015US53233
申请日期
2015.09.30
申请人
BRISTOL-MYERS SQUIBB COMPANY
发明人
VALENCIA, XAVIER;THROUP, JOHN P.;NADLER, STEVEN G.;SUCHARD, SUZANNE J.;DUCHESNE, DOMINIQUE;LIU, XIAONI;SHI, RONG;SHEVELL, DIANE E.;XIE, JENNY H.;HONCZARENKO, MAREK