Composition for Detecting Undifferentiated Human Pluripotent Stem Cell, Monoclonal Antibody 6-1 and Use Thereof

摘要

The present invention relates to a composition for detecting the undifferentiated human pluripotent stem cells comprising an agent useful for measuring the level of Desmoglein 2 (Dsg 2) mRNA or the protein thereof, a kit for detecting the undifferentiated human pluripotent stem cells comprising the said composition, a method for detecting the undifferentiated human pluripotent stem cells containing the step of measuring the level of Desmoglein 2 mRNA or the protein thereof, a method for evaluating the differentiation of human pluripotent stem cells and thereafter for separating the undifferentiated human pluripotent stem cells, a method for reducing the undifferentiated status of human pluripotent stem cells by inhibiting the expression or activation of Desmoglein 2, and a monoclonal antibody binding specifically to human Desmoglein 2.

主权项

1. A method for detecting or eliminating undifferentiated human pluripotent stem cells comprising the step of measuring levels of Desmoglein 2 mRNA or the protein thereof in separated human pluripotent stem cells.