TOLEROGENIC DENDRITIC CELLS FOR TREATING MYOCARDIAL INFARCTION AND MANUFACTURING METHOD THEREOF

摘要

Provided are the tolerogenic dendritic cells for treating a myocardial infarction and a method for preparing the same, and more particularly, the tolerogenic dendritic cells for treating a myocardial infarction, which can treat cardiac insufficiency that occurs by excessive remodeling of left ventricle in the heart muscle recovery process after an acute myocardial infarction, and a method for preparing the tolergenic dendritic cells. According to the present invention, the inflammatory reaction and the excessive remodeling of left ventricle in the heart muscle recovery process after a myocardial infarction can be inhibited, and thus, the incidence rate of cardiac insufficiency can be significantly reduced, thereby being effectively used for treating a myocardial infarction.

主权项

1. A method for preparing tolerogenic dendritic cells for treating a myocardial infarction, the method comprising culturing immature dendritic cells in a medium including TNF-α (tumor necrosis factor-α), and protein extracted from a region of a myocardial infarction of an object having a myocardial infarction or serum obtained from an object having a myocardial infarction.