HYDROXYAPATITE TISSUE FILLER AND ITS PREPARATION AND USE

摘要

The invention pertains to a biocompatible composition, suitable for use in soft or hard tissue augmentation, wherein the composition is an aqueous suspension containing a carrier fraction of ceramic particles of less than 15 μm and an augmentation fraction of ceramic particles of at least 20 μm. The ceramics typically comprise calcium phosphate. The composition is a may be used in soft tissue repair as well as hard bone replacement. It advantageously avoids the need for foreign body materials which are conventionally applied to stabilize augmentation suspensions.

主权项

1. An injectable, biocompatible aqueous suspension with ceramic augmentation particles having a size of 20 microns to 4 mm and 15-45 wt % ceramic carrier particles with 20-500 nm, wherein the sum of augmentation particles and carrier particles amounts to 30-75 wt % of the composition, said composition comprising 25-75 wt % water and optionally at least one therapeutic agent, and wherein the weight ratio of said augmentation particles to said carrier particles in said composition in a weight ratio of 0.5:1 to 10:1.