发明名称 |
METHOD FOR PREDICTING THE SOLUBILITY OF A BUFFER |
摘要 |
The invention discloses a method for predicting the solubility of at least one species at a specified pH value in an aqueous buffer comprising at least one weak acid species and/or at least one weak base species. The method comprises the steps of: a) selecting a start composition of the buffer, giving a start value for the total solute concentration; b) calculating the concentrations of all ionic species present in the buffer at the specified pH value from the total composition of the buffer and available dissociation constants; c) calculating the solubility limits of each combination of ionic species present in the buffer from available solubility products, taking the concentrations calculated in step a) into account; d) comparing the concentrations of all ionic species calculated in step a) with the solubility limits calculated in step b) and determining if any solubility limit is exceeded; e) if no solubility limit is exceeded, increasing the total solute concentration of the buffer or, if at least one solubility limit is exceeded, decreasing the total solute concentration of the buffer, and; f) repeating steps b) - e) until a predetermined convergence criteria is met. |
申请公布号 |
WO2016050566(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
WO2015EP71762 |
申请日期 |
2015.09.22 |
申请人 |
GE HEALTHCARE BIO-SCIENCES AB |
发明人 |
CARREDANO, ENRIQUE;STRANDBERG, ELENOR |
分类号 |
G01N30/34;B01D15/12;G01N30/86 |
主分类号 |
G01N30/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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