| 摘要 |
The present invention is directed generally to host cells with artificial endosymbionts, particularly magneto-endosymbionts, where the endosymbiont can be controlled and/or regulated by external means. The present invention provides artificial endosymbionts that secretes a polypeptide, nucleic acid, lipid, carbohydrate, or other factor into the host cell in a regulatable manner. In some embodiments, the polypeptide, nucleic acid, lipid, carbohydrate, or other factor secreted into the host cell by the magneto-endosymbiont imparts a phenotype to the host cell. The secreted polypeptide may be a selectable marker, a reporter protein, a transcription factor, a signal pathway protein, a receptor, a growth factor, or an effector molecule. |
