发明名称 |
AN IMPROVED EXPRESSION CASSETTE FOR PACKAGING AND EXPRESSION OF VARIANT FACTOR VIII FOR THE TREATMENT OF HEMOSTASIS DISORDERS |
摘要 |
Factor VIII variants and methods of use thereof are disclosed. In particular embodiments, Factor VIII variants are expressed more efficiently by cells over wild-type Factor VIII proteins, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced activity over wild-type Factor VIII proteins and are packaged more efficiently into viral vectors. |
申请公布号 |
WO2016025764(A3) |
申请公布日期 |
2016.04.07 |
申请号 |
WO2015US45142 |
申请日期 |
2015.08.13 |
申请人 |
THE CHILDREN'S HOSPITAL OF PHILADELPHIA;SABATINO, DENISE |
发明人 |
SABATINO, DENISE |
分类号 |
A61K38/37;C07K14/755;C12N15/00 |
主分类号 |
A61K38/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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