发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING BMP |
摘要 |
The present invention provides small molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate ceil growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascujar disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB- i 00 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia. |
申请公布号 |
WO2016054406(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
WO2015US53545 |
申请日期 |
2015.10.01 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;YU, PAUL, B.;CUNY, GREGORY, D.;MOHEDAS, AGUSTIN, H.;LEE, ARTHUR;UNIVERSITY OF HOUSTON SYSTEM |
发明人 |
YU, PAUL, B.;CUNY, GREGORY, D.;MOHEDAS, AGUSTIN, H.;LEE, ARTHUR |
分类号 |
C07D401/14;A61K31/44;A61K31/551;C07D213/02;C07D221/22;C07D401/04;C07D403/02;C07D409/04;C07D417/14 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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