SHIKONIN, ALKANNIN, AND RACEMIC PARENT NUCLEUS CARBONYL OXIME DERIVATIVES AND APPLICATIONS THEREOF

摘要

The present invention discloses derivatives of shikonin, alkannin and a racemic mixture thereof with hydroxyl methylation and carbonyl oximation on the parent nucleus, and their application. The derivatives of shikonin with hydroxyl methylation and carbonyl oximation on the parent nucleus have structural formula (I) or (II); the derivatives of alkannin with hydroxyl methylation and carbonyl oximation on the parent nucleus have structural formula (III) or (IV); the derivatives of a racemic mixture of shikonin and alkannin with hydroxyl methylation and carbonyl oximation on the parent nucleus have structural formula (V) or (VI); wherein R 1 is alkane, olefin, arene, or substituted arene comprising 1 to 6 carbon atoms; and R 2 is alkane, olefin, arene, or substituted arene comprising 1 to 6 carbon atoms or is H. The oxime derivatives of shikonin, alkannin and a racemic mixture thereof in the present invention have novel structures; and in-vitro experiments show that said derivatives of the present invention have good growth inhibitory activity against tumor cells and thus can be used in tumor treatment.