发明名称 |
Development of dengue virus vaccine components |
摘要 |
The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3' untranslated region (3'-UTR) comprising a ”30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the ”30 mutation deleted from the 3'-UTR that removes sequence in the 5' direction as far as the 5' boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3'-UTR of a dengue virus of a first serotype with the 3'-UTR of a dengue virus of a second serotype, optionally containing the ”30 mutation and nucleotides additional to the ”30 mutation deleted from the 3'-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus. |
申请公布号 |
EP2589602(B1) |
申请公布日期 |
2016.04.06 |
申请号 |
EP20120182319 |
申请日期 |
2007.08.15 |
申请人 |
THE GOVERNMENT OF THE U.S.A., AS REPR. BY THE SECRETARY, DEPT. OF HEALTH & HUMAN SERVICES, THE NAT.INST. OF HEALTH |
发明人 |
WHITEHEAD, STEPHEN S.;BLANEY, JOSEPH E.;MURPHY, BRIAN R.;CHING-JUH LAI |
分类号 |
C07H21/04;A61K39/00;A61K39/12;A61K39/42;C12N7/00 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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