摘要 |
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine. Also disclosed herein are methods for treating, preventing or diagnosing a disease associated with neuronal cell death, e.g., a neurodegenerative disease. |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;BIOMOL INTERNATIONAL L.P. |
发明人 |
SINCLAIR, DAVID;TSAI, LI-HUEI;NGUYEN, MINH;HOWITZ, KONRAD;ZIPKIN, ROBERT;BITTERMAN, KEVIN J. |