Composition and method of <i>Lactobacillus reuteri </i>GMNL-89 in treating type 2 diabetes

摘要

Present invention features a novel use of Lactobacillus for treating type 2 diabetes, wherein the Lactobacillus is Lactobacillus reuteri GMNL-89 with the deposition numbers of BCRC 910340 and CCTCC M 207154 and comprises of live, dead bacteria or supernatant of the bacterial culture(s) and a pharmaceutically acceptable vehicle. The invention also discloses the efficacies of the indicated Lactobacillus strain including anti-oxidative enzyme activity, anti-inflammation, reduction of blood glucose level, reduction of triglycerides, reduction of total cholesterol, reduction of LDL, increase of HDL and improve insulin utilization.

主权项

1. A method for treating type 2 diabetes and its complications, comprising administrating a probiotic composition, wherein the probiotic composition comprises supernatant of the live bacterial cultures of Lactobacillus reuteri GMNL-89 with the deposition number of CCTCC M 207154; wherein the live bacterial cultures are cultured at least 16 hours; wherein the supernatant is filtrated via filter membrane to filter out bacteria cells; the total protein of the administrating supernatant is adjusted to 20 μg/ml or 100 μg/m1; a daily dose of the administrating supernatant is 9.7 mL/day.