Autoimmune and inflammatory disorder therapy

摘要

Compounds that bind to phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) and inhibit the binding of PI4KIIIβ to its substrate and/or inhibit PI4KIIIβ activity may be used in the treatment and/or prevention of an autoimmune or inflammatory disorder, or organ or cell transplant rejection. A new assay for identifying compounds for use in treating and/or preventing those pathological conditions, which comprises measuring the inhibition of PI4KIIIβ activity, is also disclosed.

主权项

1. A method of treating an autoimmune or inflammatory disorder or inhibiting organ or cell transplant rejection that comprises administering to a patient in need of such treatment an effective amount of a compound that inhibits phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity.