发明名称 β- and γ-diketones and γ-hydroxyketones as Wnt/β-catenin signaling pathway activators
摘要 The present application discloses a compound which is; which activates Wnt/β-catenin signaling and thus treats or prevents diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.
申请公布号 US9303010(B2) 申请公布日期 2016.04.05
申请号 US201414547858 申请日期 2014.11.19
申请人 Samumed, LLC 发明人 Kumar KC Sunil;Wallace David Mark;Hood John;Barroga Charlene F.
分类号 C07D409/06;A61K31/357;A61K31/381;C07D319/16;C07C49/784;C07D213/50;C07D319/18;C07D405/06;C07D405/10;C07D407/10;C07D409/10;A61K9/00 主分类号 C07D409/06
代理机构 Fish & Richardson P.C. 代理人 Fish & Richardson P.C.
主权项 1. A compound which isor a pharmaceutically acceptable salt thereof.
地址 San Diego CA US