Line leaf inula flower lactone A and methods for preparing and using the same for treating myocarditis

摘要

Preparation and application of line leaf inula flower lactone A for treating myocarditis having a structure of;
The compound shows positive therapeutic activity against Coxsackie virus and significant dose dependent correlation. The line leaf inula flower lactone A prevents disease in mouse models of experimental autoimmune myocarditis and onset of the process by intraperitoneal injection of a dose of 20 mg/kg/d. When increased to 100 mg/kg/d, the line leaf inula flower lactone A shows positive therapeutic effect on EAM. Line leaf inula flower lactone A is used as the sole active ingredient and combined with a conventional pharmaceutical carrier in a drug for treating myocarditis, and the pharmaceutical composition may be in the form of tablets, dispersible tablets, mouth collapse tablets, retard tablets, capsule, soft capsule, dropping pill, granules, injection, powder injection, or aerosol.

主权项

1. A method for treating myocarditis comprising
administering to a subject in need of treatment for myocarditis a therapeutically effective amount of the pharmaceutical composition comprising a compound being a line leaf inula flower lactone A having a structure of wherein the amount of the line leaf inula flower lactone A in the pharmaceutical composition is about 10 mg to 100 mg per kilogram of weight of a subject to be treated for myocarditis.