Inkjet printing of tissues and cells

摘要

Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.

主权项

1. A method of forming microparticles comprising one or more cells encapsulated by a substrate, said method comprising printing a composition comprising said cells and said substrate into a solution that promotes gelling of the substrate,
wherein said substrate comprises alginate, and wherein said solution that promotes gelling of the substrate comprises divalent cations, to thereby form said microparticles, wherein said microparticles comprise a membrane of said substrate encapsulating 10 cells or less in at least 50% of the printed cells.