| 发明名称 | Purification of taxanes | ||
| 摘要 | Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane. | ||
| 申请公布号 | US9303004(B2) | 申请公布日期 | 2016.04.05 |
| 申请号 | US201414188416 | 申请日期 | 2014.02.24 |
| 申请人 | Phyton Holdings, LLC | 发明人 | Johnson James H.;Sambandam T. G.;Hand Barry J.;Howe Christopher D.;Franke Roland R.;Bucher Brian A.;Juchum John S.;Gallagher Rex T.;Plante Marc A.;Desimone, III Edward M.;Yang Dong S. |
| 分类号 | C07D305/00;C07D305/14;C07D407/12 | 主分类号 | C07D305/00 |
| 代理机构 | Norton Rose Fulbright US LLP | 代理人 | Norton Rose Fulbright US LLP |
| 主权项 | 1. A method of crystallizing docetaxel comprising: (a) combining docetaxel and at least one solubilizing solvent selected from the group consisting of methyl-tert-butyl ether, tetrahydrofuran (THF), methanol, ethanol, isopropyl alcohol, and acetonitrile to obtain a solution; and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel. | ||
| 地址 | San Antonio TX US | ||