| 发明名称 | Sustained-release pharmaceutical composition | ||
| 摘要 | Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition. | ||
| 申请公布号 | US9301917(B2) | 申请公布日期 | 2016.04.05 |
| 申请号 | US201113824598 | 申请日期 | 2011.10.14 |
| 申请人 | Kyoto University;Kyoto Prefectural Public University Corporation;Kaken Pharmaceutical Co., Ltd.;Koken Co., Ltd. | 发明人 | Fukushima Masanori;Matsubara Hiroaki;Matoba Satoaki;Hijikata Shigeki;Aso Yu;Sato Tsutomu |
| 分类号 | A61K38/00;A61K9/00;A61K31/7004;A61K31/7008;A61K45/06;A61K38/39;A61K9/51;A61K47/26;A61K47/42;A61K38/27;A61K38/18 | 主分类号 | A61K38/00 |
| 代理机构 | Kilyk & Bowersox, P.L.L.C. | 代理人 | Kilyk & Bowersox, P.L.L.C. |
| 主权项 | 1. A sustained-release pharmaceutical composition, comprising: a drug; a collagen, wherein the collagen is isolated atelocollagen; and at least one kind of sugar selected from a group consisting of a monosaccharide, a disaccharide, a trisaccharide, and a tetrasaccharide, which inhibits gelation of collagen, wherein the sustained-release pharmaceutical composition has a pH of from 4.0 to 10.0, and wherein the sustained-release pharmaceutical composition is in a liquid form before administration to a body, and has a property of undergoing gelation after the administration. | ||
| 地址 | Kyoto JP | ||