发明名称 LIPOPLEX FORMULATIONS FOR SPECIFIC DELIVERY TO VASCULAR ENDOTHELIUM
摘要 The present invention is related to a lipid composition contained in and/or containing a carrier comprising at least a first lipid component, at least a first helper lipid, and a shielding compound which is optionally removable from the lipid composition under in vivo conditions, whereby the lipid composition containing carrier has an osmolality of about 50 to 600 mosmole/kg, preferably about 250 - 350 mosmole/kg, and more preferably about 280 to 320 mosmole/kg, and/or whereby liposomes formed by the first lipid component and/or one or both of the helper lipid and the shielding compound in the carrier have a particle size of about 20 to 200 nm, preferably about 30 to 100 nm, and more preferably about 40 to 80 nm.
申请公布号 CA2649630(C) 申请公布日期 2016.04.05
申请号 CA20072649630 申请日期 2007.04.20
申请人 SILENCE THERAPEUTICS AG 发明人 KAUFMANN, JORG;KEIL, OLIVER;SANTEL, ANSGAR
分类号 A61K9/127;A61K47/48 主分类号 A61K9/127
代理机构 代理人
主权项
地址