Hydrophilic gels derived from grafted photoinitiators

摘要

The invention provides a method for the manufacture of a gel, said method comprising the steps of: providing a matrix composition comprising a polymeric photoinitiator of the general formula (I): Polymer-[CR2—CHR-Spacer(PI)n]m (I) curing the matrix composition by exposing it to UV radiation and exposing the matrix composition to a swelling medium. The invention also relates to gels obtainable via the above method. The invention provides a hydrophilic gel precursor manufactured from the polymeric photoinitiator of Formula (I). Medical devices comprising the gels and hydrophilic gel precursors of the invention are provided. The invention also provides the use of a polymeric photoinitiator in the manufacture of a gel.

主权项

1. A method for the manufacture of a hydrophilic gel, said method comprising the steps of:
a) providing a matrix composition comprising a polymeric photoinitiator of the general formula:
Polymer-[CR2—CHR—C(═O)—O—X-(PI)n]m  (IIa)wherein m is an integer greater than 1 to 5000;n is a real number above 0 and below 5; andPI is a photoinitiator moiety;X is selected from the group consisting of a single bond, a C1-C25 linear alkylene, a C3-C25 branched alkylene, a C3-C25 cycloalkylene, an arylene, a heteroarylene, an amine, an amide, an alcohol, an ether, an ester, a thioether, a sulfone and derivatives thereof, a sulfonic ester and derivatives thereof, a sulfoxide and derivatives thereof, a carbonate, a ketone and a polymeric moiety,and wherein each R group is a substituent independently selected from hydrogen, C1-C25 linear alkyl, C3-C25 branched alkyl, C3-C25 cycloalkyl, aryl, heteroaryl, —OH, —CN, halogens, —NR′R″, where R′ and R″ are alkyl groups or CONR′R″ or R′CONR″—, where R′ and R″ are alkyl groups, b) curing the matrix composition obtained in step a) by exposing it to UV radiation, c) exposing the matrix composition to a swelling medium, thus providing a hydrophilic gel, wherein step c) may take place before or after step b).