| 发明名称 |
Methods and compositions for the treatment of insulin-associated medical conditions |
| 摘要 |
A method of increasing insulin content in a pancreatic beta cell is disclosed. The method comprising expressing in the pancreatic beta cell an exogenous polynucleotide encoding at least one microRNA or a precursor thereof, wherein the microRNA is selected from the group consisting of miR-15, miR-16, miR-24, miR-26, miR-27, miR-29, miR-30, miR-129, miR-141, miR-148, miR-182, miR-200, miR-376 and Let-7, thereby increasing the insulin content in the pancreatic beta cell. |
| 申请公布号 |
US9301981(B2) |
申请公布日期 |
2016.04.05 |
| 申请号 |
US201514588945 |
申请日期 |
2015.01.04 |
| 申请人 |
Yeda Research and Development Co. Ltd. |
发明人 |
Hornstein Eran;Melkman-Zehavi Tal;Oren Roni |
| 分类号 |
C07H21/02;C07H21/04;A61K48/00;A61K35/39;C12N5/071;C12N15/113;A61K31/713;A61K38/46;A01K67/027 |
主分类号 |
C07H21/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A nucleic acid construct comprising a nucleic acid sequence encoding a microRNA or a precursor thereof said nucleic acid sequence being operably linked to a pancreatic beta cell specific promoter, and wherein said microRNA is selected from the group consisting of miR-15, miR-16, miR-24, miR-26, miR-27, miR-29, miR-129, miR-141, miR-148, miR-182, miR-200, miR-376 and Let-7. |
| 地址 |
Rehovot IL |
