Anti-hDlk-1 antibody having an antitumor activity in vivo

摘要

The present invention provides: antibodies specifically reacting against hDlk-1 and having anti-tumor activity in vivo (anti-hDlk-1 antibodies, and in particular, humanized anti-hDlk-1 antibodies); fragments of the antibodies; hybridomas that produce the antibodies; a complex of the antibody or antibody fragment and an agent; a pharmaceutical composition, a tumor therapeutic agent, a tumor diagnostic agent and an agent for inducing apoptosis in tumor cells, each of which comprises the aforementioned antibody or the like; a method for treating tumor, a method for detecting tumor, a method for inducing apoptosis in tumor cells, a kit for detecting and/or diagnosing tumor and a kit for inducing apoptosis in tumor cells, each of which comprises the use of the aforementioned antibody or the like; etc.

主权项

1. An antibody against human delta-like 1 homolog (Drosophila) (Dlk-1), wherein the amino acid sequence of the H chain V region comprises the amino acid sequence as shown in any one of SEQ ID NO: 35, 40, 69, 73, 77, 81, 85 and 89, and the amino acid sequence of the L chain V region comprises the amino acid sequence as shown in SEQ ID NO: 45.