| 发明名称 | Immunogenic polypeptides comprising a scaffold polypeptide and a L2 polypeptide or a fragment thereof | ||
| 摘要 | The present invention relates to an immunogenic polypeptide comprising a) a scaffold polypeptide, and b) a L2 polypeptide or a fragment of said L2 polypeptide, wherein said scaffold polypeptide constrains the structure of said L2 polypeptide, or of a fragment of said L2 polypeptide. Moreover, the present invention relates to a vaccine comprising said immunogenic polypeptide. The present invention is also concerned with a method for producing an antibody against human papillomavirus. Also encompassed by the present invention is an antibody obtained by carrying out the said method. | ||
| 申请公布号 | US9303082(B2) | 申请公布日期 | 2016.04.05 |
| 申请号 | US200913140793 | 申请日期 | 2009.12.17 |
| 申请人 | DKFZ Deutsches Krebsforschungszentrum | 发明人 | Mueller Martin;Rubio Ivonne;Tommasino Massimo;Ottonello Simone;Bolchi Angelo |
| 分类号 | A61K39/395;C07K16/08;A61K39/12;C07K14/005;C12N7/00;A61K39/385;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Foley & Lardner LLP | 代理人 | Foley & Lardner LLP |
| 主权项 | 1. An immunogenic fusion polypeptide comprising: (a) a scaffold polypeptide selected from the group consisting of thioredoxin polypeptides, and thioredoxin polypeptides from thermophile bacteria; and (b) a L2 peptide as set forth in one of SEQ ID NOs: 1-15, 20-22 and 31-479, wherein the scaffold polypeptide constrains the structure of the L2 peptide. | ||
| 地址 | Heidelberg DE | ||