发明名称 |
Compositions and methods for treating diseases of the nail |
摘要 |
Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed. |
申请公布号 |
US9302009(B2) |
申请公布日期 |
2016.04.05 |
申请号 |
US201313943165 |
申请日期 |
2013.07.16 |
申请人 |
Dow Pharmaceutical Sciences, Inc. |
发明人 |
Winckle Gareth;Fieldson Gregory T. |
分类号 |
A01N43/64;A61K31/41;A61K47/24;A01N43/653;A61K9/00;A61K9/06;A61K9/08;A61K9/10;A61K31/4192;A61K31/4196;A61K31/454;A61K47/10;A61K47/14;A61K47/18;A61K47/22;A61K47/34;A61K47/44 |
主分类号 |
A01N43/64 |
代理机构 |
Kilpatrick Townsend & Stockton LLP |
代理人 |
Kilpatrick Townsend & Stockton LLP |
主权项 |
1. A pharmaceutical composition for the topical treatment of a disorder of the nail or nail bed comprising
a. ethanol, 50% to 70% (w/w), b. cyclomethicone, 10% to 15% (w/w), c. diisopropyl adipate, 8% to 15% (w/w), d. C12-15 alkyl lactate, 8% to 15% (w/w), e. antioxidant, 0.001% to 0.50% (w/w), and f. (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)butane-2-ol, 2% to 15% (w/w); wherein the composition is formulated as a solution; wherein the surface tension of the composition is 40 dynes/cm or less; and wherein the composition does not comprise a polymeric film forming compound. |
地址 |
Petaluma CA US |