| 发明名称 | D-amino acid derivative-modified peptidoglycan and methods of use thereof | ||
| 摘要 | The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker. | ||
| 申请公布号 | US9303068(B2) | 申请公布日期 | 2016.04.05 |
| 申请号 | US201314092262 | 申请日期 | 2013.11.27 |
| 申请人 | The Regents of the University of California | 发明人 | Bertozzi Carolyn R.;Sloan Siegrist Palmore Mary;Jewett John C.;Gordon Chelsea G.;Shieh Peyton |
| 分类号 | A61K39/35;C07K9/00;A61K47/48;C12Q1/02;C07K14/47;C12Q1/18 | 主分类号 | A61K39/35 |
| 代理机构 | Bozicevic, Field & Francis, LLP | 代理人 | Bozicevic, Field & Francis, LLP ;Borden Paula A.;Foulds Glenn J. |
| 主权项 | 1. An isolated, modified peptidoglycan (PG) comprising at least one modified D-amino acid chemically conjugated to a reagent via a heterocycle, wherein the modified D-amino acid is an azide-modified, an alkyne-modified, or a norbornene-modifed D-amino acid, and the reagent is an azide-containing reagent, an alkynyl reagent or a norbornene-reactive reagent. | ||
| 地址 | Oakland CA US | ||