| 主权项 |
1. A chromatographic separation material comprising:
a cross-linked, organic polymer particle, wherein the cross-linked organic polymer particle is a styrene-based cross-linked polymer and/or a (meth)acrylic-based polymer, and the weight of the cross-linking monomer is more than 10% of the total weight monomers; and a cyclofructan compound of Formula (I): wherein: n is 1-3; each L is, independently, OR, CR3, NR2R, O—C(═O)—R, O—C(═O)—NR2—R, NR3C(═O)—NR2R, orsubstituted with R;
each R is, independently, H, (C1-C20)alkyl group optionally substituted with 1-3 R1, (C3-C20)cycloalkyl group optionally substituted with 1-3 R1, (C5-C50)aryl group optionally substituted with 1-3 R1, heteroaryl group optionally substituted with 1-3 R1, (C1-C20)alkoxy (C1-C20)alkyl group, H2C═CH—(when L is O—C(═O)—R), H2C═C(CH3)—(when L is O—C(═O)—R), alkylenyl-N═C═O; arylenyl-N═C═O; —SO2R5 (when L is OR), ═SO3 (when L is OR), (C5-C50)aryl(C1-C20) alkyl group optionally substituted with 1-3 R1, or saccharide residue lacking a hydroxy group (when L is OR), or a covalent bond to cross-linked organic polymer; R1 is, independently, (C1-C10)alkyl group optionally substituted with 1-3 R6, halo group, hydroxy group, —NR3R4, —COOR2, —COR2, nitro group, trihaloalkyl group, or —Si(OR2)3; R2 is, independently, H or (C1-C10)alkyl group; R3 is, independently, H or (C1-C10)alkyl group; R4 is, independently, H or (C1-C10)alkyl group; R5 is, independently, (C1-C20)alkyl group optionally substituted with 1-3 R1, (C5-C50)aryl optionally substituted with 1-3 R1, or heteroaryl optionally substituted with 1-3 R1; R6 is, independently, halo group, hydroxyl group, —NR3R4, —COOR2, —COR2, nitro group, trihaloalkyl group or —Si(OR2)3; wherein at least one R is a covalent bond to the cross-linked organic polymer particle, and wherein the chromatographic separation material is selected from the group consisting of: wherein Polymer is the cross-linked organic polymer particle, CFs is the cyclofructan compound of Formula (I) having 6, 7 or 8 fructose moieties, and IP is isopropyl. |
