Composition and method for treatment of diabetes

摘要

The present invention relates to a method of treating an incretin related disease such as diabetes, obesity and the like by delivery of butyric acid, bile acid, long chain fatty acid or glutamine to the colon by bypassing the upper digestive tract. The composition is combined either by the same or different route of administration with a monoamine reuptake inhibitor such as buproprion.

主权项

1. A method of treating type II diabetes in an individual consisting of:
a) selecting glutamine formulated to release in an oral colon targeted delivery system; b) orally administering sufficient formulated glutamine to the individual via a colon targeted delivery system sufficient to treat type II diabetes, wherein the amount of glutamine administered is in the range of 0.3 to 30 mg/kg body weight per day; and c) orally administering an amount of a monoamine reuptake inhibitor to the individual sufficient to ameliorate an increase in compulsive behavior caused by step b.