发明名称 |
COUMARIN DERIVATIVES AND METHODS OF USE IN TREATING CYSTIC FIBROSIS, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, AND MISFOLDED PROTEIN DISORDERS. |
摘要 |
Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis and chronic obstructive pulmonary diseases). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided. |
申请公布号 |
MX2015013173(A) |
申请公布日期 |
2016.04.04 |
申请号 |
MX20150013173 |
申请日期 |
2014.03.14 |
申请人 |
DISCOVERYBIOMED, INC. |
发明人 |
ERIK SCHWIEBERT;JOHN STREIFF;JOHN DIXON;HONGWU GAO |
分类号 |
C07D417/04;A61K31/4196;A61K31/422;A61K31/4245;A61K31/427;A61K31/433;A61K31/4427;A61K31/519;A61K31/5377;A61P11/00;A61P11/12;C07D405/04;C07D413/04;C07D471/04;C07D491/052;C07D493/04 |
主分类号 |
C07D417/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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