| 摘要 |
PROBLEM TO BE SOLVED: To provide a standard ATL model cell and model animal which is easy to control the degree of gene mutation, and easy to equalize the quality, to provide a model cell and model animal comprising an actual development factor of ATL, in which the general pathology of ATL is reflected, to provide an ATL model cell and model animal which has a higher production efficiency and needs a short time until the production.SOLUTION: The invention provides T-cells in which HBZ genes, apoptosis suppressor genes, and TCR signaling related genes are introduced and optionally CDKN2A is knocked out, an ATL model animal in which the cells are introduced, and a method for evaluating ATL therapeutic or preventive agents using cells and animals thereof.SELECTED DRAWING: None |
