Compact Mass Spectrometer

摘要

A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyser, a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in the third vacuum chamber. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.

主权项

1. A miniature mass spectrometer comprising:
an atmospheric pressure ionisation source; a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of said first vacuum chamber and a third vacuum chamber located downstream of said second vacuum chamber; an ion detector located in said third vacuum chamber; a first RF ion guide located within said first vacuum chamber; a second RF ion guide located within said second vacuum chamber; wherein the ion path length from said atmospheric pressure sampling orifice or capillary to an ion detecting surface of said ion detector is ≦400 mm; wherein the mass spectrometer further comprises: a tandem quadrupole mass analyser, a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in said third vacuum chamber; wherein the product of the pressure P1 in the vicinity of said first RF ion guide and said length L1 of said first RF ion guide is in the range 10-100 mbar-cm; and wherein the product of the pressure P2 in the vicinity of said second RF ion guide and said length L2 of said second RF ion guide is in the range 0.05-0.3 mbar-cm.