发明名称 |
MODIFIED BIOTIN-BINDING PROTEIN, FUSION PROTEINS THEREOF AND APPLICATIONS |
摘要 |
The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed. |
申请公布号 |
US2016090404(A1) |
申请公布日期 |
2016.03.31 |
申请号 |
US201514946372 |
申请日期 |
2015.11.19 |
申请人 |
Malley Richard;Lu Yingjie;Zhang Fan |
发明人 |
Malley Richard;Lu Yingjie;Zhang Fan |
分类号 |
C07K14/31;C07K14/195 |
主分类号 |
C07K14/31 |
代理机构 |
|
代理人 |
|
主权项 |
1. A fusion protein comprising a biotin-binding protein comprising amino acid sequence of at least 85% sequence identity to SEQ ID NO: 1 fused to a protein or a peptide. |
地址 |
Beverly MA US |