DELIVERY DEVICES AND METHODS FOR GASTROINTESTINAL IMPLANTS

摘要

Several gastrointestinal surgery procedures are effective as treatments for metabolic disorders such as obesity and diabetes. Minimally invasive procedures including intra-luminal gastrointestinal implants have been proposed to mimic the anatomical, physiological and metabolic changes achieved by these procedures. Many of these designs include long sleeve like elements that prevent contact of food with the walls of the small intestine. It is desirable to have simple delivery systems that can place these implants under endoscopic guidance. However, in order to anchor these sleeve elements safely and reliably, the inventors have previously disclosed anchoring means that anchor the sleeves at the junctions of the stomach and the intestine or the stomach and esophagus.

主权项

1. A system for delivery and implantation of a gastrointestinal device within one or more of a pyloric antrum, a pylorus, a duodenal bulb, a duodenum, and a jejunum of a patient's gastrointestinal tract, the system comprising:
an anchor having a collapsed configuration for delivery and an expanded configuration for anchoring within one or more of the pyloric antrum, the pylorus, and the duodenum; an intestinal bypass sleeve coupled to and extending from an end of the anchor; an anchor delivery catheter having an anchor capsule coupled to a proximal outer sheath, both the capsule and the proximal outer sheath having a central longitudinal lumen, wherein a diameter of the capsule portion of the central lumen is sized and configured to retain the expandable anchor in the collapsed configuration; and a pusher catheter slideably disposed within the central longitudinal lumen of the anchor delivery catheter, the pusher catheter having a coupling feature disposed within the anchor capsule and the pusher catheter defining an internal lumen; wherein the coupling feature is adapted to engage the anchor such that the coupling feature is operable to deploy the anchor from the anchor capsule; an outer sheath delivery catheter slideably disposed partially within the internal lumen of the pusher catheter and having a distal portion extending distal to the distal end of the anchor delivery catheter, the sleeve delivery catheter having an internal lumen; and an inner sheath delivery catheter slideably disposed within the internal lumen of the outer sheath delivery catheter, wherein the inner sleeve delivery catheter has a sleeve retention feature disposed at or near a distal end.