ANTI-AGEING COMPOSITION COMPRISING RESVERATROL AND ANDROGRAPHOLIDE

摘要

The invention relates to an oral anti-ageing composition, in particular to an oral anti-ageing composition comprising resveratrol and an aqueous or hydroalcoholic extract of the leaf and whole herb of Andrographis paniculata. The inventors have observed a synergistic up-regulation of haemoxygenase-1 (HO-1) in primary human dermal fibroblast cells treated with a combination of aqueous extract of the whole herb of Andrographis paniculata and resveratrol. Thus in a first aspect of the invention, an oral anti-ageing composition is provided, the oral anti-ageing composition comprising resveratrol and an aqueous or hydroalcoholic extract of the leaf and whole herb of Andrographis paniculata, wherein the oral or topical anti-ageing composition comprises more than 0.4 % w/w andrographolide, wherein the oral anti-ageing composition comprises a daily dosage of 10 to 500, preferably 50 to 300 mg resveratrol in the form of one or more unit doses. Other aspects of the invention are also described.