CHELATE-CONTROLLED DIASTEREOSELECTIVE HYDROGENATION WITH HETEROGENEOUS CATALYST

摘要

A catalyst,method of using, and use of a hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support. This in the presence of lithium salts, with salts such as theborates being preferred. This provides hydrogenation of precursors to give rise to a stereoselective, such as diastereoselectivebias in the product of alkene hydrogenation using the catalyst. This equation, using the preferred substrate, best illustratesthe invention: